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Doktorandenstelle/PhD Position (Life Sciences)

A 3-year PhD Position (E13, 65% ) is available in the department of Membrane Biochemistry at the Life & Medical Sciences Institute from the University of Bonn. The group's main research focus is on the structure and function of biological membranes (see also our website "membiol.uni-bonn.de").

This particular project has an emphasis on the mechanisms by which the Amyloid Precursur Protein (APP), which is involved in Alzheimer's disease, forms protein clusters in the plasma membrane. Applying a spectrum of modern imaging techniques (superresolution microscopy, TIRF microscopy and FRAP) it is planned to study how APP clustering in the plasma membrane is related to its processing by secretases.

The applicant should have graduated in biology/biochemistry or a related subject.

For general reading see:

Sieber, J.J., Willig, K.I., Kutzner, C., Gerding-Reimers, C., Harke, B., Donnert, G., Rammner, B., Eggeling, C., Hell, S.W., Grubmüller, H. and Lang, T. (2007). Anatomy and dynamics of a supramolecular membrane protein cluster. Science 317, 1072-1076 

Saka, S.K., Honigmann, A., Eggeling, C., Hell, S.W., Lang, T. and Rizzoli, S.O. (2014). Multi-protein assemblies underlie the mesoscale organization of the plasma membrane. Nat. Commun. 5, 4509


For special reading see:

Schreiber, A., Fischer, S. and Lang, T. (2012). The Amyloid Precursor Protein Forms Plasmalemmal Clusters via Its Pathogenic Amyloid-beta-Domain. Biophys. J. 102, 1411-1417
 
How to apply:
Please send your application by Email to:

thorsten.lang@uni-bonn.de
 
Send application to
Prof. Dr. Thorsten Lang
E-Mail: thorsten.lang@uni-bonn.de
Telefon: 0228-73 62 823

Life & Medical Sciences Institute, Universität Bonn, Membrane Biochemistry Lab
Carl-Troll-Str. 31
53115 Bonn
 
While applying for the job please refer to jobvector and use the following reference number: Amyloid Precursur Protein

About Life & Medical Sciences Institute, Universität Bonn

The Life & Medical Sciences Institute (LIMES) is a center of excellence for both basic research and higher education in Life Sciences and Biomedicine at the University of Bonn. It provides a framework for cutting-edge multidisciplinary research and offers young scientists early independence and responsibility. A common scientific focus of the LIMES Institute is to study cell signalling...

More about Life & Medical Sciences Institute, Universität Bonn

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