Identification of the role of Cyp2c44- and sEH-derived lipids in lymphangiogenesis and tumour metastasis
“Identification of the role of Cyp2c44- and sEH-derived lipids in lymphangiogenesis and tumour metastasis”
in the laboratory of Prof. Dr. Ingrid Fleming (Vascular Research Centre Frankfurt am Main, http://www.vrc.uni-frankfurt.de/VRCKart/Center/ ).
This project will focus on the roles of specific tumour enriched fatty acid epoxides and diols on lymphangiogenesis and their link to metastasis. Previous data from murine tumour models will be backed up with in vitro studies (e.g. thoracic duct sprouting assay) aimed at determining the molecular mechanisms involved. Depending on the results obtained, MS-based proteomic and metabolomic studies will be included.
The Else Kröner-Fresenius Research Training Group “Eicosanoid and sphingolipid pathways in inflammation, cancer and vascular diseases” is an international research training group at the Goethe University Frankfurt and the Karolinska Institute in Stockholm and is funded by the Else Kröner-Fresenius-Stiftung. The focus of this research training group is on intensifying the understanding of the physiological and pathophysiological roles of eicosanoids and sphingolipids in inflammatory processes, cancer and vascular diseases. FIRST provides postgraduate education in all aspects of translationals biomedicine with a focus on the processes involved in drug research and development.
Candidates should already possess a first class MSc (biology, pharmacy or related discipline) or an MD degree. Applications consisting of a cover letter indicating the motivation for this project as well as a full curriculum vitae containing a brief summary of previous research projects, together with copies of all relevant university certificates should be sent by email to Dr. Brigitte Held (email@example.com). Hard copy version can be to the postal address: Dr. Brigitte Held, Institut für Pharmazeutische Chemie, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, D - 60438 Frankfurt. Incomplete applications will not be considered.
The application deadline is May 22nd, 2016. Short listed applications will be required to attend a selection workshop in Frankfurt.
Stipends will be paid according to the rules of the Deutsche Forschungsgemeinschaft.
For further information on the projects as well as FIRST, please visit: www.first-gradschool.de
Applications by email preferred.
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Institut für Pharmazeutische Chemie
Goethe Universität Frankfurt
D - 60438 Frankfurt
About Johann Wolfgang Goethe Universität Frankfurt am Main
The graduate centre FIRST is a unique organization of the Johann Wolfgang Goethe University of Frankfurt, the Georg Speyer Haus (GSH) and the Paul Ehrlich Institute (PEI) in Langen. At Frankfurt University, groups within the faculties Medicine (FB16) and Biochemistry, Chemistry and Pharmaceutical Sciences (FB14) that address different aspects of drug research from basics up to clinical...More about Johann Wolfgang Goethe Universität Frankfurt am Main