PhD Position

The Institute of Molecular and Cell Physiology, Medical school Hannover is looking for a talented and motivated PhD candidate of all nationalities with an interest in biophysics, cell biology, molecular biology and nanotechnology.

Institute of Molecular- und Cell Physiologie
Medizinische Hochschule Hannover
OE4210, Gebäude I3 Block 1 Ebene 03
Carl-Neuberg-Str.1, 30625 Hannover,
Germany

Activities and responsibilities

Project description:

Single point mutations in the β-cardiac myosin heavy chain (β-MHC) are among the most frequent cause of Hypertrophic Cardiomyopathy (HCM) in humans that affect 1 in 500 individuals worldwide. Clinical phenotypes display a high variability ranging from being asymptomatic, to rapidly progressive failing heart or sudden cardiac death in young individuals and competitive athletes. The characteristic features of HCM include thickening of the left ventricular wall and the inter-ventricular septum of the heart, cardiomyocyte disarray, and interstitial fibrosis. Among other sarcomereic proteins, the molecular motor protein β-MHC is reported to harbour >300 single point mutations, dispersed throughout the molecule, accounting for about 40% of all HCM cases. So far, however, neither a common pattern of functional defects was found for the different HCM-related mutations nor effective treatment strategies.
The project aims to investigate functional changes in the β-MHC motor properties, induced by HCM-mutations, using state-of-the-art single molecule function investigation techniques, such as Total internal Reflection fluorescence microscopy (TIRF) and optical tweezers.

What we are looking for:

- We expect excellent academic scores, prior research experience but most importantly, commitment and enthusiasm to face the many challenges of a Ph.D. project.

- Good English knowledge

- Participation in teaching tasks in the physiology in limited scope is desired. German language skill is therefore a plus.

Key competences:

Analytical and goal-oriented approach, willingness to take responsibility, willingness to learn, patience,flexibility and reliability.

Qualification profile

We welcome applications from candidates (m/f/d) with a master degree in biophysics, biomedicine, biology, biochemistry, cell biology, molecular biology and related areas (Life Sciences).

Application

The application should include a CV and a short summary of previous research experience (if any).

The position is funded with a Deutsche Forschungsgemeinschaft (DFG) grant. The MHH is committed to promoting women in professional life. Applications from women are therefore particularly welcome.

Benefits

We offer:
  • The PhD position funded for 3 years (50% of TV-L E13).
  • An international and exciting working atmosphere
  • Stateof-the-art research facilities and a chance to work with experts from interdisciplinary background
  • An exciting project with defined objectives and clinical significance
For more information on the lab’s research interests - visit the group site at
https://www.mh-hannover.de/molzell_mitarbeiter.html

Send application to

Dr. Mamta Amrute-Nayak,
Principal investigator, Molekular- und Zellphysiologie
Medizinische Hochschule Hannover
OE4210, Carl-Neuberg-Str.1, 30625 Hannover, Germany
Gebäude I3 Block 1 Ebene 03

While applying for the job please refer to jobvector and use the following reference number: MA-2810

About Medical School Hannover

Institute of Molecular and Cell Physiology Medical school Hannover Carl-Neuberg Strasse 1 30625 Hannover  
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