PhD position 13: Epidemiolomics of thrombin generation in thrombo-inflammation (Marseille/Mainz)

We offer a PhD position for biomedical doctoral students at the Center for CardioVascular and Nutrition research (C2VN at Aix-Marseille Université, France) and the Center for Thrombosis and Hemostasis (University Medical Center Mainz, Germany). As this project is part of the MSCA ITN “Thrombo-Inflammation in Cardiovascular Disease” (TICARDIO), you will be trained in an international, interdisciplinary joint doctoral degree program striving to train the next generation of biomedical researchers. Your PhD project will be supervised by Prof. Dr. Pierre Morange in Marseille and Prof. Dr. Sven Danckwardt in Mainz. Furthermore, a research stay at Bayer (Wuppertal, Germany, Dr. Stefan Heitmeier) offers you the opportunity to get insights into research in the industry.

Activities and responsibilities

Project description
Thrombin is the central coagulation protease implicated in thrombosis and inflammation. Thrombin generation tests are widely used for assessing thrombosis risk, but limited data are available on their predictive value for thrombo-inflammatory and vascular diseases. Our hypothesis is that the integration of multi-omics data and a system biology approach will disclose how thrombin generation profiles are altered in the plasma from patients with thrombo-inflammatory disease.
At C2VN, you will identify new determinants of thrombin generation by using a multi-omics approach and information from several study cohorts. Thrombin generation will be measured in plasma from 750 patients with venous thrombosis from the Marseille Thrombosis Association (MARTHA) study. You will apply advanced statistical methods to identify miRNA patterns related to thrombin generation, and then verify positive associations in independent groups of patients. You will integrate the omics data available in MARTHA together with the coagulation, inflammation and clinical phenotypes to come to a more comprehensive analysis of the regulatory mechanisms of coagulation pathways. At Bayer, you will perform additional bioinformatics analysis to link the miRNA to effects of anticoagulants in preclinical and clinical data sets. You will then functionally validate candidate miRNA patterns at CTH, using a miRNA-target interaction atlas in combination with regulatory assays, RNA-binding proteins and other post-genomic changes. The new possible biomarkers will be validated in the cohorts of Gutenberg Health Study, SCACORO and AtheroGene studies.

Qualification profile

>> You have a Master degree (or equivalent) in biomedical sciences or a similar field
>> You are in the first four years of your research career and do not hold a doctoral degree
>> Your must not have resided in France for more than 12 months in the 3 years prior to the recruitment
>> Ideally, you have an affinity for bioinformatics and statistical analysis.

Benefits

Benefits of working in an ITN
>> You will be working within our international group of > 30 researchers
>> You will be involved in cutting-edge research in an interdisciplinary environment
>> You will contuct your research at two research locations and the site of an industry partner
>> You will receive excellent network-wide and local training with conference participation
>> You will receive a 36 months contract with all national social security (and family allowance, if applicable) at the Aix-Marseille Université
>> You will optain a joint doctoral degree from Universities of Marseile and Mainz, if all requirements are fullfilled

How to apply
Please visit www.ticardio.eu for information about the recruitment process and all required application documents.

Application deadline: July 15, 2019

Send application to

How to apply
Please visit www.ticardio.eu for information about the recruitment process and all required application documents.

While applying for the job please refer to jobvector and use the following reference number: JV-50056785

About Universitätsmedizin Mainz

Center for thrombosis and hemostasis The scientific activities of the researching physicians and scientists of the medical units of the Mainz University Medical Center are characterized by a broad content spectrum. In recent years, university medicine has been able to confirm its national and international position through a large number of excellent publications and the acquisition of...
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