PhD position 15: Phenotyping atherothrombosis in patients at risk of cardiovascular disase (Maastricht/Mainz)

We offer a PhD position for biomedical doctoral students at the School for Cardiovascular Disease in Maastricht (CARIM, Netherlands) and the Center for Thrombosis and Hemostasis (University Medical Center Mainz, Germany). As this project is part of the MSCA ITN “Thrombo-Inflammation in Cardiovascular Disease” (TICARDIO), you will be trained in an international, interdisciplinary joint doctoral degree program striving to train the next generation of biomedical researchers. Your PhD project will be supervised by Prof. Hugo ten Cate/Dr. Paola van der Meijden/Dr. Henri Spronk in Maastricht and by Prof. Philipp Wild in Mainz. Furthermore, a research stay at 2M Engineering (Valkenswaard, Netherlands, Gillian Mimnagh) offers you the opportunity to get insights into research in the industry.

Activities and responsibilities

Project description
Hypercoagulability (HC) and cell signalling by protease-activated receptors contribute to the risk of atherothrombotic events. The consequences of HC may depend on the population background (genetic and phenotypic) and the cardiovascular risk profile. We hypothesize that HC aggravates atherosclerosis, contributes to plaque instability, and promotes atherothrombosis in patients at increased cardiovascular risk and in healthy subjects.
You will assess associations between HC and inflammation in plasma from patients with thrombotic diseases, in comparison to healthy subjects. Associations are determined by targeted assays, a novel point-of-care platelet counter, in situ platelet activity and integral coagulation assays. You will assess the plasma coagulation status and compare this with other cardiovascular properties. Patient plasma samples with low/high thrombotic and/or inflammatory propensities will be used to evaluate the therapeutic potential of new pathway inhibitors. At the CTH, the results will be compared with data from the population-based Gutenberg Health Study (GSH), regarding risk associations between HC, inflammation markers, cardiovascular complications and coagulation phenotypes, linked to genomics analyses. Additional measurements in a sub-cohort are: (i) platelet count and activity assays; (ii) coagulation protease activity measurements; (iii) multi-marker inflammation and vascular activation array; (iv) integrated coagulation testing including thrombin generation and thromboelastography. At 2M engineering, you will participate in the development and use of the prototype point-of-care test for assessing platelet reactivity.

Qualification profile

>> You have a Master degree (or equivalent) in epidemiology, biomedical sciences or a similar
>> You are in the first four years of your research career and do not hold a doctoral degree
>> Your must not have resided in the Netherlands for more than 12 months in the 3 years prior to the recruitment
>> Ideally, you have thorough biomedical interest and knowledge, wet laboratory skills and an interest and/or knowledge of handling large data sets.

Benefits

Benefits of working in an ITN
>> You will be working within our international group of > 30 researchers
>> You will be involved in cutting-edge research in an interdisciplinary environment
>> You will contuct your research at two research locations and the site of an industry partner
>> You will receive excellent network-wide and local training with conference participation
>> You will receive a 36 months contract with all national social security (and family allowance, if applicable) at CARIM.
>> You will optain a joint doctoral degree from Universities of Maastricht and Mainz, if all requirements are fullfilled

How to apply
Please visit www.ticardio.eu for information about the recruitment process and all required application documents.

Application deadline: July 15, 2019

Send application to

How to apply
Please visit www.ticardio.eu for information about the recruitment process and all required application documents.

While applying for the job please refer to jobvector and use the following reference number: JV-50056785

About Universitätsmedizin Mainz

Center for thrombosis and hemostasis The scientific activities of the researching physicians and scientists of the medical units of the Mainz University Medical Center are characterized by a broad content spectrum. In recent years, university medicine has been able to confirm its national and international position through a large number of excellent publications and the acquisition of...
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