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PhD position (Epigenetics & Gene Regulation): Developmental Mechanisms Underlying Stress Resilience

In the field of “Developmental Mechanisms Underlying Stress Resilience”, the research group of Professor Soojin Ryu offers the following PhD project:

Characterization of novel early life stress-induced molecules in the hypothalamus

The Hypothalamic-Pituitary-Adrenal (HPA) axis and its final effector, glucocorticoids (GCs), are key players in mediating the stress response and are important for maintaining homeostasis in the face of adverse conditions. However, overexposure to GCs during early life can permanently alter how an animal behaves in the future. The hypothalamus, which represents an important neuroendocrine center of the brain, represents one of the main target sites of GCs. Yet, very little is known about how the hypothalamus is altered as a consequence of exposure to a stressor or overexposure to GCs during development. To address this question, we have 1) developed an early life stress paradigm, 2) performed hypothalamic-specific cell sorting of transgenic zebrafish that have been exposed to such a paradigm, and 3) performed whole genome transcriptome analysis using next generation sequencing. This work identified a set of hitherto unchracterized genes that are highly regulated in animals that have been exposed to early life stress. These molecules then promise to reveal unknown molecular mechanism by which stress exposure during development can shape an animals’s future performance. The goal of this project is then to characterize and determine the mechanism by which these genes function. The project will involve using diverse techniques available in the lab including biochemistry, imaging and behavioral analysis.

We offer
  • The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
  • A stimulating, diverse and international research environment
  • Advanced training opportunities
  • A fully funded PhD position
Required qualifications
  • Master or Diploma
  • Motivation to solve complex biological problems
  • Excellent communication skills
Further requirement
  • 2 letters of reference
Duration of stipend/salary: 3 years, with the possibility of extension
Starting date: 1 August 2017 or later
Deadline for registration (exclusively online via web form): 24 March 2017

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While applying for the job please refer to jobvector and use the following reference number: JV-C12-SR

About Institute of Molecular Biology gGmbH

Our International PhD Programme on the “Gene Regulation, Epigenetics and DNA Damage Response” gives talented and enthusiastic students the opportunity to undertake PhD research at the cutting edge of modern biology. Our groups cover a broad range of expertise and include leading biochemists, geneticists, cell and developmental biologists who study the molecular mechanisms of...

More about Institute of Molecular Biology gGmbH

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