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PhD position (Epigenetics & Gene Regulation): Regulation of Inflammatory Responses of the Blood Brain Barrier

In the field of “Regulation of Inflammatory Responses of the Blood Brain Barrier”, the research group of Professor Ari Waisman offers the following PhD projects:

Inflammatory responses of the blood brain barrier endothelial cells      

Description:
 
We are currently searching for a highly motivated PhD student with strong interest in molecular biology and immunology, to investigate the role of members of the NF-kB family of transcription factors for the function of the blood brain barrier (BBB) endothelial cells during inflammation.
 
We have recently identified Bcl-3, an atypical inhibitor of NF-kB signaling, to be involved in the function of T-lymphocytes. We found that Bcl-3 inhibits the binding of two NF-kB molecules, p50 and p65, to their target genes. As a consequence, Treg and Th17 cells do not develop properly, which leads to the spontaneous development of gut inflammation. Similarly, we found that deletion of the NF-kB-inducing kinase (NIK) in T cells leads to their inability to differentiate to pathogenic T cells.    
 
In the frame of the PhD project we seek to better understand the role of Bcl-3 and NIK in the response of the BBB endothelial cells. Furthermore, we will modulate A20, which is another enzyme that is involved in the NF-kB pathway specifically in the BBB. The student will use state-of-the-art culture systems that model mouse and human BBB and in addition conditional gene targeting in mice, to delete or overexpress these genes and study their importance for the function and integrity of the BBB.
 
We offer
  • The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
  • A stimulating, diverse and international research environment
  • Advanced training opportunities
  • A fully funded PhD position
 
Required qualifications
  • Master or Diploma
  • Motivation to solve complex biological problems
  • Excellent communication skills
 
Further requirement
  • 2 letters of reference
 
Duration of stipend/salary: 3 years, with the possibility of extension
Starting date: 1 August 2017 or later
Deadline for registration (exclusively online via web form): 24 March 2017


For further questions and contact information please check our website:
www.imb.de/PhD/


Please apply exclusively via our online form at:
www.imb.de/students-postdocs/international-phd-programme/apply-to-ipp/
 
 
 

Contact detail


How to apply:
Please apply exclusively via our online form at:
www.imb.de/students-postdocs/international-phd-programme/apply-to-ipp/
Send application to
For further questions and contact information please check our website:
www.imb.de/PhD/

Job profile


Working hours
Full-Time
Contract duration
Temporary
Type of job
PhD Project
Work experience
job experience is not required
Region
Germany (Rheinland-Pfalz)
Working place
55128 Mainz
Area of expertise
Biology & Life Sciences