PhD Position (Epigenetics & Nuclear Dynamics): Superresolution microscopy of intrinsically disordered proteins in nuclear architecture enabled by chem

The IPP Mainz winter call 2019/2020 is open.

Thinking of doing your PhD in Molecular Biology? The International PhD Programme (IPP) on “Epigenetics, Gene Regulation & Genome Stability” is offering talented, young scientists the chance to work at the cutting edge of research. The IPP has a community of exceptional scientists working on diverse topics. These range from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory. This means that no matter where your PhD project takes you, there is always someone to go to for advice or collaborations.
As part of the IPP, you will be given advanced training, covering skills needed for both research and industry. Access to our state-of-the-art Core Facilities and their technical expertise ensures that you are supported no matter how challenging or expansive your project becomes. Importantly, as an IPP student, you are offered a fully funded position with financing until the completion of your thesis. To help you integrate and settle in Mainz, IPP students organise and run a lively social programme with activities to suit everyone.
The IPP is coordinated by the Institute of Molecular Biology (IMB) — a modern research centre located on the bustling campus of Mainz University in Germany. The IPP currently has over 120 energetic students from 30 countries working on innovative research at IMB, Mainz University and its University Medical Centre.
Are you an ambitious, young scientist looking to push back the boundaries of science while interacting with colleagues from multiple disciplines and cultures? Then the IPP is your opportunity to give your scientific career a flying start!

Activities and responsibilities

In the field of “Epigenetics & Nuclear Dynamics”, the IPP research group of Dr Edward Lemke offers the following PhD project:

Superresolution microscopy of intrinsically disordered proteins in nuclear architecture enabled by chemical and/or biophysical tool development

In higher eukaryotes, proteins that lack apparent folded structure are enriched in many vital processes. The Lemke group studies interactions between intrinsically disordered proteins and structured proteins in vital cellular processes, such as nuclear transport, gene regulation and host pathogen interactions. The nuclear pore complex is the probably largest known proteinaceous assembly that regulates all traffic across the nuclear envelope. About two thirds of the proteins form a scaffold structure, while the other third is disordered and forms a highly dynamic permeability barrier of elusive structure that gives the nuclear pore complex its unique ability to function as the logistic center of the nucleus. Since such highly dynamic systems are inaccessible by most conventional approaches, the group applies a multidisciplinary approach combining single molecule, microfluidics, super-resolution techniques and chemical/synthetic biology tools.
Superresolution microscopy of intrinsically disordered proteins in nuclear architecture enabled by chemical and/or biophysical tool developmentAs part of an ERC funded project “Next generation Single Molecule Protein Fluorescence” as well as large consortia on pathogen mechanisms ( we are now looking for a PhD student with a strong interest in further expanding quantitative single molecule and super resolution based technologies to understand the molecular mechanisms of intrinsically disordered nucleoporins. The project will be highly interdisciplinary, and there are multiple aspects to it, that can be filled by one or two different persons with different interests/backgrounds.On the one hand, the project is well suited for candidates with a strong background in physics or physical sciences in general, such as advanced fluorescence techniques, soft matter sciences, optical engineering, data analysis and image processing, physical chemistry and/or computer heavy disciplines, as well as experience in programming.The project is also well suited for candidates with a strong background in synthetic organic chemistry, chemical biology, synthetic biology, protein engineering, protein evolution, molecular biology and/or cell biology.In all cases, extensive project training will be provided that candidates with little or even prior no-hands on experience in the experimental biosciences but the strong wish to engage into those are particularly encouraged to apply. High interest and motivation are the main selection criteria and candidates from other disciplines that want to venture into these areas are explicitly welcome to apply.

Qualification profile

  • Master or equivalent
  • Motivation to work at the forefront of science
  • Interactive personality & good command of English
  • 2 letters of reference

We offer

  • The possibility to work on exciting, multidisciplinary projects using state-of-the-art technology in highly motivated research teams
  • To be part of a lively and international community of about 120 IPP students from 30 countries
  • Numerous opportunities for advanced professional training in scientific knowledge, techniques and professional skills
  • Fully funded positions until completion of thesis
Starting date: 1 March 2020 – 1 September 2020
Duration of stipend/salary: 3 years, with the possibility of extension

Deadline for registration (exclusively online via web form): 19 November 2019

Send application to

Please find all relevant information on the application process at:

While applying for the job please refer to jobvector and use the following reference number: JV-C18-EL

About Institute of Molecular Biology gGmbH

Our International PhD Programme on the “Gene Regulation, Epigenetics and DNA Damage Response” gives talented and enthusiastic students the opportunity to undertake PhD research at the cutting edge of modern biology. Our groups cover a broad range of expertise and include leading biochemists, geneticists, cell and developmental biologists who study the molecular mechanisms of embryonic...
More about Institute of Molecular Biology gGmbH