PhD Position in Life Sciences
Regulation of mitochondrial protein biogenesis under pathophysiological conditions
Mitochondria are essential organelles that consist of about 1,000 different proteins. Most of these proteins are synthesized in the cytosol from where they are imported into mitochondria. The components of the translocation machinery of the outer and inner membrane have been identified and the principles by which they mediate protein translocation studied in some detail. However, we have very little understanding of the mechanisms that regulate mitochondrial protein biogenesis. In this project, we will address two questions: (i) how do different redox conditions in the cell modulate protein translocation into mitochondria, and (ii) how do cytosolic aggregates interfere with the import of mitochondrial precursors? Both projects have high biological and medical relevance. We are looking for PhD students interested in biochemistry, genetics, proteomics and, due to the close collaboration with our partners in Canada, in molecular medicine.
The program includes a 6-months stay in a lab of our Canadian partners and offers excellent scientific and transferable skills training at all participating locations. The program language is English and there are no tuition fees. The successful candidate will receive a contract (65% TVL13), as well as support with administrative matters, accommodation, visas etc. We invite applications from highly qualified and motivated students of any nationality and we are looking forward to your application for the PhD fellowship in our group.
Please only use our online application form (http://www.irtg1830.com/application/).
While applying for the job please refer to jobvector and use the following reference number: IRTG1830-CellBiology
Department of Plant Physiology
Faculty of Biology
University of Kaiserslautern
Phone: + 49 (0)631-205-3633
Fax: +49 (0)631-205-2600
About IRTG 1830
Dysfunction of membrane proteins and of protein compartmentalization can seriously compromise normal functioning of cells and organs, and has been implicated in detrimental diseases. Moreover, altered activity of many membrane proteins causes dramatic effects on developmental and cellular adaptation processes in animal and plant cells. The IRTG 1830 aims to investigate selected membrane...More about IRTG 1830