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PhD position in Molecular Tumor Biology

 Universität Würzburg  Würzburg
Our Goal:
Our central research topic is the role of the Myc oncoprotein in cancer biology. We want to understand, how Myc functions in health and disease on a molecular level. We use new techniques like NGS (Next generation sequencing) to gain whole-genome information about Myc induced cellular changes (RNA-Seq, Gro-Seq) and Myc binding (ChIP-Seq). Recently we characterized the binding profile of Myc (Walz et al., Nature 2014; Vo*, Wolf* et al, Cancer Cell 2016) and its binding partner Miz1 (Wolf et al, Nature Communications 2013) in several systems. Overall, we could identify new mechanisms, which can explain Myc´s important role in tumorigenesis (Wolf et al, Trends in Cell biology, 2015). In the future we want to analyze how Myc communicates with the RNA polymerases to regulate transcription. The ultimate goal is the development of strategies how Myc´s function in tumors can be blocked.

Motivated applicants should have a strong background in molecular biology and biochemistry and should have excellent lab skills. An interest in bioinformatics is needed, as sophisticated analyses are part of the project, however previous knowledge is not necessary. Applications from severely handicapped persons with basically similar qualification will be given priority. Salary will be according to TV-L (E13).

We offer:
The successful candidate will be part of a DFG-Emmy Noether research group (Dr. Elmar Wolf) located within the institute of Biochemistry and Molecular Biology headed by Prof. Martin Eilers. This constellation provides both, tight supervision in a well-thought-out project and the scientific background of one of the world-leading institutes working on Myc. The institute provides excellent equipment allowing state-of-the-art experiments and the candidate will learn techniques, which are highly beneficial for her or his later carrier in academia or industry. The PhD-position will be embedded in the graduate school of life science, ensuring an efficient and speedy PhD process.

Applications (brief cover letter describing previous research experience and interests, CV, certificates and the contact details of two referees) should be sent per e-mail (subject: ”PhD MYC”) until 10.02.2016 to:
How to apply:
Send application to
Dr. Elmar Wolf
Biozentrum der Universität Würzburg
Lehrstuhl für biochemie und Molekularbiologie
Am Hubland, 97074 Würzburg
While applying for the job please refer to jobvector and use the following reference number: PhD MYC

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