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PhD Project The role of hyaluronan fragments in lymphangiogenesis – a biophysical approach

We are one of 83 institutes of the "Max Planck Society for the Advancement of Science". Our main focus lies in fundamental research. Currently, we have a staff of about 270, in three scientific departments and one Max Planck research group.
 
Location: Biophysical Chemistry, University Heidelberg in collaboration with the Max Planck Institute for medical Research, Heidelberg
Project supervisor: Heike Boehm
 
Cellular interactions are not only guided by molecular biochemical interaction, but also influenced by biophysical cues and the chemical presentation of the ligands. In this PhD project the successful candidate will explore the biophysical and chemical parameters guiding lymphangiogenesis, the formation of new lymph vessels. In particular, we will focus on the role of the glycosaminoglycan hyaluronan – a key component of the extracellular matrix. Hyaluronan polymers are immunosuppressive, anti-angiogenic and impede cell differentiation. However, fragments of hyaluronan show opposite effects and induce lymphangiogenesis. To this day, the mechanistic cause for the size dependent bioactivity of hyaluronan remains elusive.
 
Inspired by the role of hyaluronan in lymphangiogenesis, this project aims to uncover the mechanisms by which hyaluronan induces intracellular signals. The interdisciplinary approach is based on specific, well-defined model systems and functionalization strategies and will include primary cell experiments.
 
The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.
Furthermore, the Max Planck Society seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply.
 
The contract is available initially for three years. The successful applicant will receive a salary according to the funding guidelines for PhD Students of the Max-Planck Society.
 
Applications should include a CV, a list of publications (if applicable) and contact names and addresses of one to three references familiar with the work of the candidate. Please submit al materials preferably in electronic form (as one single PDF file) via e-mail with references to the code number 02/2016 until July, 31 st 2016 to jobs@vw.mpimf-heidelberg.mpg.de
 
Related References:
Minsky, B. B. et al. Controlled Immobilization Strategies to Probe Short Hyaluronan-Protein Interactions. Sci. Rep. 6, 21608; doi: 10.1038/srep21608 (2016).
Rausch, S. et al. Polarizing cytoskeletal tension to induce leader cell formation during collective cell migration. Biointerphases J. 8:32; DOI: 10.1186/1559-4106-8-32 (2013).
 

Max Planck Institute for Medical Research
POB 10 38 20
69028 Heidelberg, Germany
http://www.mpimf-heidelberg.mpg.de/en

Contact detail


How to apply:
preferably in via email until July, 31st 2016
Send application to
Applications should include a CV, a list of publications (if applicable) and contact names and addresses of one to three references familiar with the work of the candidate. Please submit al materials preferably in electronic form (as one single PDF file) via e-mail with references to the code number 02/2016 to jobs@vw.mpimf-heidelberg.mpg.de

Job profile


Working hours
Full-Time
Contract duration
Temporary
Type of job
PhD Project
Work experience
job experience is not required
Region
Germany (Baden-Württemberg)
Working place
69120 Heidelberg
Area of expertise
Biology & Life Sciences, Chemistry, Biotechnology, Material Science & Engineering
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