Molecular mechanisms governing normal and leukemic hematopoietic stem cell biology for advanced regenerative medicine and cancer therapy   
The LOEWE Center for Cell and Gene Therapy (, financed by the state of Hesse, has been established to develop novel therapy approaches for cardiovascular, oncological and hematological diseases. The center brings together research groups from the University Hospital Frankfurt, the Georg-Speyer-Haus, the Paul-Ehrlich-Institute, the Institute of Transfusion Medicine and the Max-Planck Institute for Heart and Lung Function, generating a center for excellent basic and clinical science regarding cell and gene therapy research.
The Department of Hematology at the Goethe University Hospital Frankfurt offers the entire spectrum of diagnostics and therapy of malignant diseases of the hematopoietic system. Special research interests are acute leukemias. It is part of the University Center for Tumor Diseases (UCT). This ensures high-level integrated treatment in the interdisciplinary planning of diagnostics, therapy, and care of tumor patients.
The PhD student position (to aim for Dr. rer. nat. or equivalent) is available from 1. October 2015.
The position is based in the experimental research laboratory of Prof. Dr. Michael Rieger at the Department of Hematology of the Goethe University Hospital Frankfurt. The group is integral part of the LOEWE Center for Cell and Gene Therapy and is well-established in the local scientific community (e.g. SFB834) and in national and international research consortia (e.g. German Cancer Consortium). For further information please visit .
The project aims for the elucidation of novel molecular mechanisms that govern hematopoietic stem cell biology and fate decision control. Utilizing these mechanisms will advance hematopoietic stem cell-based cell and gene therapies in regenerative medicine. Further, the dysregulation of these mechanisms ultimately will lead to blood disorders and leukemia, and therefore provide a window of opportunity for the development of advanced therapies against leukemia stem cells. We address central questions in hematopoiesis and leukemia with a large spectrum of cellular and molecular biology methods, state-of-the-art cell sorting and novel time-lapse imaging and single cell tacking (Rieger et al., Science 325, 2009; Thalheimer et al., Stem Cell Rep. 2014; Rabenhorst et al., Cell Rep. 2015), and relevant mouse models.
Highly motivated candidates with an outstanding university degree in biology, biochemistry or a related study will gain from a young dynamic international environment with scientific excellence. Fascination for modern biomedical research and enjoyment in experimental work are more relevant than previous work experience. However, a strong background in stem cell biology, oncology or cell biology might be of advantage. Experience in flow cytometry / FACS-based cell sorting and in working with mouse models would be beneficial. A research visit abroad is possible due to many international collaborators.
As an equal opportunities employer, the Goethe University Hospital has set itself the strategic aim of significantly increasing the proportion of women in research and academia. Female scientists are therefore particularly encouraged to apply. Applications from abroad are especially welcome. Equally qualified candidates with disabilities will be given preference.
If you are interested in joining this ambitious team in an exciting field of stem cell research, then please direct the complete application (only email PDF) including a brief summary of previous research experience and two references until 21st September 2015 to
Prof. Dr. Michael Rieger,
Please do not send any original documents since we will not be able to return them.

How to apply:
only by email (please combine all documents in a single PDF)
Send application to
Prof. Dr. rer. nat. Michael Rieger
LOEWE Center for Cell and Gene Therapy Frankfurt

Department for Hematology/Oncology
Goethe-University Hospital Frankfurt
Building 25, 1st floor, room 103
Theodor-Stern-Kai 7
60590 Frankfurt (Main)


While applying for the job please refer to jobvector and use the following reference number: MR-2015/1

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Das Universitätsklinikum Frankfurt unterstützt den Fachbereich Medizin der Stiftungsuniversität Frankfurt am Main bei dessen Aufgaben in Forschung und Lehre und steht mit ihm für international anerkannte Spitzenforschung und hochwertige  und forschungsnahe Patientenversorgung. Mit 1200 Betten in 25 Kliniken und Instituten bietet es das gesamte Spektrum medizinischer...

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