PhD Student Position: Quantitative live cell single molecule imaging

The Laboratory for Molecular Imaging (Group leader: Dr. Maximilian Ulbrich) at the BIOSS Centre for Biological Signalling Studies of the University of Freiburg invites applications for a
PhD Student Position
“New labeling strategies for quantitative single molecule imaging of membrane proteins”

The complex rules that govern the assembly of neurotransmitter receptors in synapses provide the molecular basis for the diverse functional repertoire of nerve cells. We recently developed a single molecule based imaging approach to decipher the composition of these receptors with unmatched precision. However, the availability of suitable fluorescent protein markers currently restricts the number of useable colors to two. The goal of this project is to develop novel approaches to utilize the potential of organic dye markers for imaging three or more colors simultaneously. The newly established labeling strategies will not only be applied to resolve the composition of membrane proteins, but also for other single molecule methods like superresolution imaging.

The work in the Ulbrich laboratory includes wet lab biology (cloning, biochemistry, cell culture), instrumentation (assembly of custom single-molecule microscopes), and programming to control equipment and evaluate results. Ideally, applicants should bring enthusiasm for science, creativity, technical and programming skills, as well as experience in microscopy, molecular biology and/or biochemistry. Ph. D. candidates should be independent and motivated individuals who hold a Diploma or M.Sc. degree in Biology, Physics, Chemistry or a related discipline.

The project is initially funded for 3 years by the German Research Foundation DFG but can be extended if required. Please include a CV with a cover letter, the names of at least two references and a statement of research interests that makes clear the motivation to pursue the PhD in the Ulbrich Laboratory. Please submit your application electronically as a single pdf file to:
How to apply:
Please send a single pdf file per email.
Send application to
Dr. Maximilian Ulbrich
University of Freiburg
BIOSS Centre for Biological Signalling Studies
While applying for the job please refer to jobvector and use the following reference number: MU-JV1

About Albert-Ludwigs-Universität Freiburg

The Albert-Ludwigs-University Freiburg is one of the oldest universities in Germany. Freiburg is located in the South-West corner of Germany close to France and Switzerland. BIOSS is the Cluster of Excellence in Freiburg funded by the Excellence Initiative from the German government. The aim of BIOSS is to gain a more detailed functional and quantitative understanding of the working principles...

More about Albert-Ludwigs-Universität Freiburg

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