Phylogeny and Function of Vγ9Vδ2 T cells: Human vs. Camelids

The Institute of Virology and Immunobiology at the Julius Maximilians Universität Würzburg,
research group Prof. Dr. Thomas Herrmann (Immunogenetics)
offers a position for a docotral researcher in immunology as part of a DFG funded project

“Phylogeny and Function of Vγ9Vδ2 T cells: Human vs. Camelids“
(German salary scale TV-L E13 65%, 3 years)

Activities and responsibilities

Project Description

Vγ9Vδ2 T cells recognize and respond to host and microbial metabolites (phosphoantigens). These cells are massively expanded in infectious diseases such as malaria and exert antimicrobial and anti-tumor function. They were believed to exist only in higher primates until we recently identified them in a camelid species (alpaca). The project aims to compare the γδ T cells of both species and to investigate mechanisms of antigen recognition. To this end, we will compare the T-cell antigen receptor (TCR) repertoire of phosphoantigen-stimulated cells of both species. Furthermore, molecular mechanisms of antigen-recognition will be elucidated by generating and investigating wild-type, chimeric and mutated forms of TCRs as well as of molecules which play a key role in “phosphoantigen presentation“.
The project is part of the newly founded DFG research group "Receiving and Translating Signals via the gamma-delta T Cell Receptor" and a collaboration with the Vetmeduni Vienna.

More information about our group can be found at:
http://www.virologie.uni-wuerzburg.de/en/immunology/immunological-lab-groups

Qualification profile

Your profile
  • Master’s Degree/Diploma in immunology, biology, biochemistry or a related field of the life sciences
  • Strong English communication and presentation skills (written and spoken)
  • Ability to work in an international team and a strong desire to do research with high self-motivation and enthusiasm
  • Experience in molecular biology techniques, cell culture and flow cytometry are advantageous
  • Willingness to actively contribute to the PhD student program “Immunomodulation” (http://www.gk-520.uni-wuerzburg.de)  within the Graduate School of Life Sciences (https://www.graduateschools.uni-wuerzburg.de/life-sciences)
  • Equally well qualified disabled applicants will be given preference

Benefits

We offer
  • German salary scale TV-L E13 65%, 3 years
  • Participation in DFG research group "Receiving and Translating Signals via the gamma-delta T Cell Receptor" and a collaboration with the Vetmeduni Vienna
  • Participation in Graduate School of Life Sciences at the University of Würzburg

Send application to

Application

Please send your application as single pdf-file to Prof. Herrmann (herrmann-t@vim.uni-wuerzburg.de) by 15 Oct 2018. The application should include:
  • Cover letter indicating current and future research interests and career goals
  • A description of research experience and accomplishments including a summary of the master thesis (maximum 2 pages), and a list of publications if applicable
  • CV including copies of degree certificates and transcript of grades and two letter of recommendation or two references including current supervisor
For additional information, please contact:
Prof. Thomas Herrmann (herrmann-t@vim.uni-wuerzburg.de)
While applying for the job please refer to jobvector and use the following reference number: GSLS20182

About University of Würzburg, Graduate School of Life Sciences

The Graduate School of Life Sciences (GSLS) Interdisciplinary research training is the key to the success of tomorrow's life scientists. The University of Würzburg provides for a world class environment of research institutions , which have a long standing and successful tradition of co-operation across faculties. The GSLS results from a common initiative of the Faculties...

More about University of Würzburg, Graduate School of Life Sciences

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