Team Leader Protein Production and Purification (m/f)
Protagen AG develops innovative diagnostic solutions for the improvement of diagnosis, drug development and therapy in autoimmune diseases. We believe that our employees are our most important asset and are dedicated to provide encouraging working conditions, challenging tasks as well as individual employee development programs.
Leading our team for protein production, characterization and purification
Cloning and recombinant protein expression in either E. coli, insect cells or mammalian cells
Development of downstream purification processes and strategies for proteins produced in recombinant expression systems
Characterization and selection of proteins to be used in in vitro diagnostic kits and assays as well as R&D applications
Product oriented use and application of state-of-the-art protein purification technologies and analytical methods, e.g. IMAC, RP, IEX, and SE chromatography, SDS-PAGE, Western blot, HPLC, and mass spectrometry etc.
Write/revise SOPs, protocols, technical reports, and presentations
Establishment and implementation of standard protein purification processes for product candidates and reagents
Support the Quality Management System to meet applicable regulatory requirements (such as ISO9001:2008, ISO 13485:2003)
Experience and Qualifications:
PhD or MSc or Engineer in Biology, Biochemistry, Biotechnology AND preferably more than 3 years of expertise in recombinant protein production as well as protein chemistry / biochemistry and purification of recombinant proteins
In-depth knowledge and expertise of cloning and protein production in different expression systems (E. coli, insect cells, mammalian cells) also in high throughput systems
Expert in various protein separation and downstream processing techniques including affinity, ion exchange, hydrophobic, and size exclusion chromatography
Experience in the development and application of physico-chemical analytical methods such as HPLC (size exclusion, reverse phase), spectrophotometric analyses, gel electrophoresis, MS.
Ability to manage, motivate and develop a team as well as organizational and process management skills.
Fluent in English; German at conversational level
Experience with Microsoft Office (especially Excel, Word and PowerPoint)
Experience and expertise in ISO13485 and/or ISO9001:2008 requirements
We would be pleased to receive your complete application documents via email as well as your earliest starting date and salary expectations.
Protagen AG Dr. Petra Weingarten, Director Human Resources Otto-Hahn-Straße 15, 44227 Dortmund Phone: +49 231/9742-6300 firstname.lastname@example.org
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