Doctoral candidate / PhD student in Metabolic engineering and fermentation


Doctoral candidate / PhD student in Metabolic engineering and fermentation

The Fraunhofer-Institute for molecular biology and applied ecology conducts research at the interface between academia and industry in the field of applied life sciences from a molecular level to entire ecosystems. Our interdisciplinary organization and our modern laboratories, equipped with state-of the art infrastructure, offer a broad research and development portfolio.

The division Industrial Biotechnology at the location in Aachen deals with a diverse range of topics. Some of them belong to the elucidation of the function of selected enzymes or entire biosynthetic pathways for the synthesis of natural products, e.g. secondary metabolites. The focus of the working group lies in the metabolic engineering of syngas-fermenting bacteria, which are intended to be used as biocatalysts for the synthesis of biofuels and bulk chemicals. The aim is to recycle large amounts of emitted industrial waste gas (a mixture of CO2, CO and H2) to produce valuable basic products for industry. The effect would be to preserve fossil fuels and concomitantly decrease CO2 emission to reduce ongoing climate change. For the expansion of the natural product spectrum of these bacteria we introduce complex biosynthetic pathways heterologously and investigate the cultures according to their product accumulation using GC-MS measurements. Potential bottlenecks can be determined at the level of transcript, protein and pathway intermediates to allow a straight forward optimization of the strains. After a successful proof-of-concept phase the current goal is to increase the product yield for application in industrial processes. Therefor classical methods like chemical mutagenesis and modern approaches like CRISPR/Cas9 can be used for strain development.

Your Tasks
  • Cultivation of anarobic bacteria
  • Cloning of heterologous biosynthetic pathways
  • Fermentation of bacteria in small scale and in syngas-fermenters at 3.7 L scale
  • Product analysis using GC-MS
  • High troughput screening
  • Generation, characterization and optimization of producer strains

What we expect from you
  • Masters degree in biotechnology, biology, biochemistry, bioengineering or a comparable field of study
  • Good experience in classical and / or modern cloning techniques
  • Ideally, you have knowledge in microbiology of anaerobic bacteria and fermentation
  • Expertise in application of chemical analysis (GC/MS, LC/MS and HPLC) is an advantage
  • Enrolement at a german university
  • good command of German and English (spoken and written)

Your professional qualifications are complemented by a rapid comprehension, commitment and an analytical, structured and independent approach to work. Last but not least, you have a friendly and accessible personality capable of working in a Team.

What you can expect from us
  • modern lab equipment and analysis technology
  • diverse and challenging tasks
  • an open, cooperative and competent team
  • wide range of opportunities for professional training / professional development
  • flexible working hours
  • a publicly funded project in an innovative research area with international partners from academia and industry
Appointment, remuneration and social security benefits based on the public-sector collective wage agreement (TVöD).
The position is initially limited.
In case of identical qualifications, preference will be given to severely disabled candidates.
The Fraunhofer-Gesellschaft is committed to providing equal career opportunities for men and women.

Fraunhofer is Europe’s largest application-oriented research organization. Our research efforts are geared entirely to people’s needs: health, security, communication, energy and the environment. As a result, the work undertaken by our researchers and developers has a significant impact on people’s lives. We are creative. We shape technology. We design products. We improve methods and techniques. We open up new vistas.

Send application to

Further Information or any question about this job opening please contact:
Mrs. Dr. Gabriele Philipps (phone.: +49 241-6085-13345)

Are you highly motivated to support our team with your expertise and to promote applied research and development on innovative biotechnology for industrial applications and processes?
We are looking forward to your application via the following button "Apply".
While applying for the job please refer to jobvector and use the following reference number: IME-MB-2018-12

About Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie IME

Das Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie IME ist eines von derzeit 66 Instituten und Forschungseinrichtungen der Fraunhofer-Gesellschaft, der größten Organisation für angewandte Forschung in Europa. Mit ihrer zentralen Aufgabe »Forschen für die Praxis« prägt die Fraunhofer-Gesellschaft in enger Kooperation mit ihren...

More about Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie IME

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