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Master/Diploma Thesis for the project: “Chemical synthesis of bioactive compounds and the evaluation of their cosmetic and/or food application“

 BRAIN AG  Zwingenberg
BRAIN AG is an independent and privately owned research corporation located in the RhineNeckar area in Germany that discovers and develops novel bioactive natural compounds and proprietary enzymes for its partners and customers in the chemical and pharmaceutical as well as in the food and cosmetics industries. BRAIN AG, a European leader in the field of White (industrial) Biotechnology, was founded in 1993 and currently employs >100 highly qualified personnel. BRAIN regularly incorporates life science students into project work within the company. This work always accompanies the completion of a diploma or Master‘s thesis and in some cases it can be part of a practical semester lasting at least 6 months.

We currently offer a lab project for a

Master/Diploma Thesis for the project:

“Chemical synthesis of bioactive compounds and the evaluation of their cosmetic and/or food application“

Project description:
The aim of this project is the synthesis of different derivatives by means of organic synthesis starting from a lead compound. Using cell-based assay systems, the purified products will be investigated for their bioactive properties, which are interesting for the application in cosmetics or food, e.g. anti-aging, tanning or whitening properties and anti-microbial activity.

We offer the opportunity to extend knowledge in the following methodologies:
  • Chemical synthesis and compound purification techniques
  • Determination of the chemical and physical properties by state of the art techniques
  • Investigation of the biological activity of each compound using cell-based screening assays and microbial cell systems
Necessary skills:
  • M.Sc. student in Chemistry or Biochemistry with focus on Chemical Synthesis or Organic Chemistry
  • Highly motivated and keen to independently push a project
  • Capability to perform a literature study on chemical synthesis strategies and the ability to independently plan and perform chemical syntheses are required
  • Hands-on experience in chemical synthesis with reflux, distillation, compound purification (column chromatography and thin-layer chromatography) and crystallization are a must
  • Analytical skills in gas- and liquid-chromatography and 1HNMR are helpful

How to apply:
Please send your completed application to:
Send application to
While applying for the job please refer to jobvector and use the following reference number: 160513-JV-C-JR


BRAIN AG is one of Europe’s leading technology companies in the field of industrial  biotechnology, the core discipline of bioeconomy. Based on „Toolbox of Nature“ and our proprietary BioArchive, innovative product solutions of novel bioactive natural substances, microbial producer organisms as well as previously untapped, efficient enzymes and biocatalysts are...

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