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Project for bachelor-thesis (Starting October 2015) Research group of Bioprocess Engineering

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Project for bachelor-thesis
(Starting October 2015)
 
 Research group of Bioprocess Engineering
Max-Planck-Institute for Dynamics of Complex Technical Systems Magdeburg

 
„Optimization of process parameters for the perfusion-based cultivation of an animal cell line using a tangential flow filtration (TFF) system“
 
Cell cultivation in perfusion mode consists in the continuous addition of nutrients at the same flow rate that exhausted medium enriched with the product of interest is extracted from the bioreactor. During perfusion, cells are contained within the bioreactor using a retention system, which enables to reach very high cell and product concentrations. The TFF-based retention system has proved its suitability to reach very high cell concentrations. However, operation parameters for tangential filtration should be set according to each cell line.
 
Within this project, optimal filtration parameters such as transmembrane pressure, flow rate and linear velocity, using a TFF-based perfusion system, should be established to minimize shear stress on an animal cell line. Optimal conditions should be used in further cultivations to achieve high cell concentrations.
 
 

Contact detail


How to apply:
Bitte senden Sie Ihre aussagekräftigte Bewerbung per E-Mail.

Please send your application per e-mail to
vazquez_ramirez@mpi-magdeburg.mpg.de.
Send application to
Max-Planck-Institute for Dynamics of
Complex Technical Systems Magdeburg
MSc. Daniel Vazquez
vazquez_ramirez@mpi-magdeburg.mpg.de
Tel.: 0391-6110 333
 
 
 

Job profile


Working hours
Full-Time
Contract duration
Temporary
Type of job
Bachelor thesis
Work experience
job experience is not required
Region
Germany (Sachsen-Anhalt)
Working place
39106 Magdeburg
Area of expertise
Biotechnology, Biology & Life Sciences, Chemical & Process Engineering
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