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1 PhD position “Regulation of protein transport processes into peroxisomes by kinases”

 Universität Freiburg  Freiburg
The Research Training Group 2202 „Transport across and into membranes“
at the University of Freiburg (Germany) welcomes applications for

1 PhD position “Regulation of protein transport processes into peroxisomes by kinases”
Part-time position (65%), starting date: 01.07.2016
The Research Training Group is funded by the DFG and focuses on the characterization of transport processes at a molecular level. The doctoral researchers examine the transport of ions, metabolites and proteins across and in the cell membrane using a huge variety of biochemical and biophysical techniques.
The three‐year structured program consists of lecture series, seminars, method courses, a summer school, and symposia. In addition, participants will be offered the possibility to attend courses for individual needs. Successful candidates will be awarded the PhD degree (Dr. rer. nat.). The program is taught in English.
The PhD position is open in the Department of Functional Proteomics and Biochemistry, Faculty of Biology, in the Warscheid laboratory ( and deals with the regulation of protein transport processes into peroxisomes by cytosolic kinases.
Peroxisomes harbour approximately 50 different enzymes to fulfill various metabolic functions. The biogenesis of peroxisomes involves transport of matrix proteins across the peroxisomal membrane. This process requires the concerted action of a subcellular machinery composed of numerous peroxisomal proteins, the so-called peroxins. Failure in the biogenesis of peroxisomes or deficiency in the function of single peroxisomal proteins leads to severe genetic diseases in humans. To date, the key players and basic principles of peroxisomal protein import are known, but key regulatory mechanisms underlying these processes have so far remained largely elusive. We have put the spot-light on reversible protein phosphorylation for the control of peroxisomal protein import and identified several peroxins as specific targets of cytosolic kinases. In the PhD project, kinase-mediated signaling events and their functional implications for the regulation of peroxisomal protein import in yeast and human cells will be studied. This cutting-edge research project offers the unique possibility to employ latest technologies in proteomics, biochemistry, bioinformatics, molecular and cell biology including high-resolution mass spectrometry (MS), high-performance liquid chromatography (LC), fluorescence microscopy, genome editing, protein import assays, protein phosphorylation, protein-protein interaction and kinase signaling analysis. We offer an excellent scientific environment with well-equipped laboratories including state-of-the-art LC/MS instrumentation (UHPLC/Orbitrap systems) and provide a supportive and encouraging working atmosphere in our interdisciplinary research team. We are looking for a new, highly talented, creative and motivated team member, preferably with experience in protein biochemistry, signaling research or cell biology.
  • Diploma, Master or Bachelor’s degree with honours (B.Sc. Hon. for a fast-track application) in Biochemistry, Biology, Biophysics, Chemistry, Physics, Molecular Medicine, Pharmacy or related fields
  • proven qualifications with particular relevance to either transport processes or transport proteins, esp. protein biochemistry, signal research or cell biology
  • High motivation and commitment
  • Interest in active participation in the RTG program
  • very good written and spoken English skills
Application documents:
  • Application form (fillable PDF form:
  • Letter of motivation
  • CV
  • Transcripts of studies
  • Two letters of recommendation
  • Proof of fluency in English
The maximum duration of the PhD position will be three years. The salary is in accordance with the German public service salary scale (TV‐L E 13, 65%). The job advertisement is subject to the definitive financing commitment of the DFG. Further information:
How to apply:
Applications should be sent as one pdf file to
Please refer to „Application RTG 2202“ in the subject line.
Send application to
Coordinator RTG2202:
While applying for the job please refer to jobvector and use the following reference number: 1022

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