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PhD student in Chemical Biology & Bioorganic Synthesis

The newly established Laboratory of Chemical Biology at the KU Leuven works on the development of chemical tools for the study of proteases. Proteases biology is very complex, since most proteases are synthesized as inactive zymogens and once activated, are subject to post-translational regulation. We develop and apply tools, such as activity-based probes: molecules that specifically react with active forms of proteases. Their selectivity can be adjusted by the probe structure. We also develop probes for fluorescent imaging, inhibitors for intramembrane proteases, and cleavable linkers for identification of the proteins targeted by our probes.
The project entails the synthesis of new activity-based probes for serine and cysteine proteases. This will involve a combination of solution & solid phase chemistries, and evaluation of the probes in proteomes and live cells by biochemical and mass spectrometry methods.
- MSc degree in chemistry
- Ambitious, motivated, creative and practically skillful
- Strong background and interest in bio-organic synthesis
- Experience with solution and solid phase synthesis & purification methods
- A strong interest in biochemistry
- Experience with biochemistry techniques is a plus
We offer a doctoral position for 4 years in a stimulating, interdisciplinary environment and scientific development opportunities in an international and dynamic team. You will have access to state-of-the-art research facilities and will be registered in a specific program of the doctoral school. You will be supervised by well-trained scientists and receive thorough training in conducting research, presentations and writing.
For more information, please visit or contact Prof. Dr. Steven Verhelst:, +32 16 374517.
How to apply:
Please provide a motivation letter, CV, copies of transcripts/MSc degree, and names and contact information of at least two references.
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While applying for the job please refer to jobvector and use the following reference number: BAP-2015-458

About KU Leuven - University of Leuven

Interdisciplinary Protease Research Research interests: Synthesis of activity-based proteomics tools Intramembrane protease function and mechanism

More about KU Leuven - University of Leuven

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