PhD (m/w/d) in the field of Mucosal Immunology

The Institute of Molecular Medicine at RWTH Aachen University has an opening for aPhD (m/w/d) in the field of Mucosal ImmunologyThis is a part time position ( 25,03 h/w) and offered on a temporary contract (project-related) for three years. The successful candidate has the opportunity to pursue a doctoral degree. The salary corresponds to level  13 TV-L.

Activities and responsibilities

Immune responses are regulated by the microenvironment. In the gut, intestinal epithelial cells are known to affect immune cell behavior. This is especially relevant when epithelial cells undergo malignant transformation, a process that modifies the local environment to promote tumor growth. Foxp3+ regulatory T cells (Treg) are key controllers of immune responses, and their behavior is often altered by tumors. Treg can suppress inflammation in an antigen specific way to prevent autoimmune diseases, but they can also block beneficial immune responses against tumors.You will analyze how tumor-related changes in intestinal epithelial cells affect local Treg. You will use state of the art methods of cellular and molecular biology, such as high end flow cytometry, transcriptional analysis, bioinformatics and microscopy to understand how tumor-related processes modulate the intestinal immune environment to promote tumor growth in mouse and humans.

More information can be found on our homepage (https://www.ukaachen.de/en/clinics-institutes/institute-of-molecular-medicine/research/ag-izcue.html).

Qualification profile

  • You have a strong interest in mucosal immunology
  • You have practical experience in basic lab techniques, experience with animal models, flow cytometry and histology will be an advantage
  • You are proficient in spoken and written English
  • You are highly motivated, engaged and excited to work in an international team

Benefits

The RWTH Aachen University is certified as a family-friendly university and offers a dual career program for partner hiring. We particularly welcome and encourage applications from women, disabled people and ethnic minority groups, recognizing they are underrepresented across RWTH AachenUniversity.The principles of fair and open competition apply and appointments wili be made on merit.

Send application to

Please send your application (code-no): GB-P-17461 until 31, May 2019 to the director of the Institute of Molecular Medicine, Univ.-Prof. Oliver Pabst, E-Mail: opabst@ukaachen.de.
For further information please contact: Mrs. Dr. rer. nat. Ana Izcue, Phone: +49 241 80 85782 or E-Mail: aizcue@ukaachen.de

While applying for the job please refer to jobvector and use the following reference number: GB-P-17461

About Universitätsklinikum Aachen

Die Zukunftschancen des Universitätsklinikums Aachen und der Medizinischen Fakultät der RWTH Aachen beruhen auf der Verbindung von konsequenter Patientenorientierung, effizienter Lehre und innovativer Forschung. Diese geschieht in enger Kooperation mit den ingenieur- und naturwissenschaftlichen Disziplinen der Hochschule. Für die Erfüllung aller Ziele ist wirtschaftliches...
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