PhD position in Inflammation and cancer research (m/f/d)

The Division of Gastrointestinal Oncology is looking for candidates to apply for a PhD position in Inflammation and cancer research (m/f/d)

Our group is funded by an ERC Consolidator Grant and the newly founded SFB 1382 to investigate the cell biological basis of liver diseases and the development of liver cancer. The group is integrated into the Medical Clinic III of the University Hospital Aachen, where further working groups with similar emphases are already established.

For a project on the role of microbiome and programmed cell death in the development of liver cancer we are looking for candidates for a PhD position (Dr. rer. nat./PhD), EG 13 TV-L, 65% and limited to 3 years.

Activities and responsibilities

The doctorate is conceived as a structured graduate education under the roof of the newly founded graduate school "Gut-Liver Axis" and, in addition to project-specific research work, includes interesting continuing education modules at the interface between basic-oriented life sciences and clinical research. The current project aims to investigate which interactions exist between the intestinal microbiome and the liver and how they influence the development of cancer in the liver.

Qualification profile

We are looking for highly motivated PhD students (m/f/d) with a university degree (diploma, master or equivalent) in biology, biotechnology, biochemistry, pharmacy and human biology/molecular medicine with experience in experimental research and an interest in the cellular and molecular biology of programmed cell death, immunology, microbiology, and/or bioinformatics. The desire to work in a competitive international environment and good skills of English or German (in spoken and written) are expected.

We offer

We offer a dynamic and interdisciplinary clinical and basic scientific environment and modern equipment. With 40000 students and 6000 academic staff, the RWTH is one of the largest universities in Germany. The RWTH Aachen University is certified as a family-friendly university and offers a dual career program for partner hiring. We particularly welcome and encourage applications from women, disabled people and ethnic minority groups, recognizing they are underrepresented across RWTH Aachen University. The principles of fair and open competition apply and appointments will be made on merit.

Literature:

Kather JN. et al. Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer. Nat Med. 2019.

Roy S. et al. microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis. Gastroenterology. 2018

Schneider AT. et al. RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer. Cancer Cell. 2017.

Gautheron J. et al. The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance. Nat Commun. 2016.

Send application to

For further information please contact Prof. Dr. Tom Lüdde (tluedde@ukaachen.de) or visit our homepage (https://www.ukaachen.de/kliniken-institute/klinik-fuer-gastroenterologie-stoffwechselerkrankungen-und-internistische-intensivmedizin-med-klinik-iii/forschung/ag-luedde.html).

Please send your documents including a curriculum vitae, a letter of motivation, all academic certificates and 2-3 references by email to Dr. Mihael Vucur, PhD (mvucur@ukaachen.de) by 30.11.2019 quoting the reference number: 21273.

While applying for the job please refer to jobvector and use the following reference number: reference number: 21273

About Universitätsklinikum Aachen

Die Zukunftschancen des Universitätsklinikums Aachen und der Medizinischen Fakultät der RWTH Aachen beruhen auf der Verbindung von konsequenter Patientenorientierung, effizienter Lehre und innovativer Forschung. Diese geschieht in enger Kooperation mit den ingenieur- und naturwissenschaftlichen Disziplinen der Hochschule. Für die Erfüllung aller Ziele ist wirtschaftliches Handeln eine...
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