PhD student position (m/f/d) (Biology, Biochemistry, Life Science)

The Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation offers a

PhD student position (m/f/d) (Biology, Biochemistry, Life Science)available from the next possible date for 3 years ( TV-L EG13, 65%). The position is part of the clinical research unit (CRU344) “Untangling and Targeting Mechanisms of Myelofibrosis in Myeloproliferative Neoplasms” which is funded by the German Research Foundation (DFG).

Activities and responsibilities

Myeloproliferative neoplasms (MPN) are accompanied by inflammation that arise in part through stimulation of cytokine production by the malignant clone, but which is also reinforced by cytokines secreted from the bone marrow microenvironment. MPN mesenchymal stromal cells (MSCs) of the microenvironment and their progeny often transform into cell types that support fibrotic processes. Current therapeutic strategies in chronic myeloid leukemia (CML) may reduce cytokine secretion by the malignant hematopoietic cell clone but likely fail to target the microenvironment. As a consequence, this malignant environment can further fuel altered signaling in the malignant clone besides therapy. Which factors are specifically secreted by the bone marrow niche, the cell types secreting these factors, and how this could be targeted to prevent persisting signaling in the malignant clone is not fully understood. Our recent work has revealed the role of JAK1-STAT3 signaling in the malignant clone for the persistence of malignant stem cells. Interestingly, this signaling axis is driven by the malignant microenvironment (Kuepper et al., Leukemia 2019, PMID 30842608). In the current project, the candidate will therefore explore the impact of specific microenvironmental-derived factors on the survival of malignant stem cells and will investigate the effect of cytokine inhibition in vivo, with respect to the malignant clone and the tumor niche. During this project, the candidate will utilize techniques from multiple fields such as biochemistry, molecular biology, mouse genetics and state of the art imaging.

Qualification profile

  • A diploma/ master degree in biochemistry, biology or related Life Science disciplines
  • Excellent track record with a strong background in biochemistry, tumor cell biology and molecular biology
  • Great enthusiasm for oncology research and the ability to work independently
  • Experience in (cancer) mouse models is highly advantageous but not required
  • Excellent command of English and the ability to work in a team

We offer

  • Excellent training for employing a wide range of techniques, including mouse models
  • State of the art facilities for mouse genetics, confocal microscopy, cell sorting, proteomics and genomics
  • Salary according to TV-L E13 (65%) plus benefits according to public service position
  • Modern and well-equipped laboratories in a dynamic and international environment
  • PhD intended

Send application to

The application should include a cover letter, CV, certificates, list of publications, and references. Please send your documents with reference GB-P 21443 to Dr. rer. nat. Mirle Schemionek (mschemionek@ukaachen.de) latest until the 25th of November, 2019.

For further information please contact Dr. rer. nat. Mirle Schemionek, E-Mail: mschemionek@ukaachen.de

While applying for the job please refer to jobvector and use the following reference number: GB-P 21443

About Universitätsklinikum Aachen

Die Zukunftschancen des Universitätsklinikums Aachen und der Medizinischen Fakultät der RWTH Aachen beruhen auf der Verbindung von konsequenter Patientenorientierung, effizienter Lehre und innovativer Forschung. Diese geschieht in enger Kooperation mit den ingenieur- und naturwissenschaftlichen Disziplinen der Hochschule. Für die Erfüllung aller Ziele ist wirtschaftliches Handeln eine...
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