Ph.D. Student In Radiation Therapy and Cancer Research

The university hospital Essen with over 6,000 employees in 26 clinics, 23 institutes and specialist centers and 225,000 patients per year offers medical care, state-of-the-art diagnostics and comprehensive therapy of highest international standard. In addition, there is an extensive range of services in research and teaching at an internationally competitive level. Within the DFG funded Research Training Programme “Molecular determinants of the cellular radiation response and their potential for response modulation” (GRK1739) we are looking for a PhD student.

Activities and responsibilities

Available projects are on exciting areas of investigation covering aspects of cellular responses to DNA damage, with emphasis on chromatin remodeling complexes such as SWI/SNF factors which are involved in cancer induction and are implicated in the regulation of gene expression and DNA damage-sensing. Chromatin remodelling complexes as well as chromatin modulation can influence radiation response of cancer cells. The aim of the present study is to evaluate the role of chromatin remodeling factors on DDR after combined treatment schedules with cisplatin and or repair inhibitors in cancer cell lines with epigenetic dysregulation. The results will help to develop targeted therapy options for tumors with dysfunctional chromatin remodeling factors.

Qualification profile

We are looking for enthusiastic individuals with interest in the field of cancer to join the Institute of Radiation Therapy at the University of Duisburg-Essen, Medical School, with the purpose of completing a Ph.D degree (Dr.rer. nat. or Dr. rer medic). Salary equivalent to 0.65% TV-L13. Candidates should have a degree in molecular biology, biochemistry, or a related subject, and interest in research. Experience in cellular responses to DNA damage, or cell cycle regulation, are desirable. Compensation is through a fellowship.

Benefits

Within the DFG funded Research Training Programme “Molecular determinants of the cellular radiation response and their potential for response modulation” (GRK1739) we are looking for a PhD student.

The University of Duisburg-Essen is an equal opportunity employer. Applications of women are appreciated. In cases of similar qualification, competence and specific achievements women will be considered in equal terms within the legal framework. Handicapped candidates with equal qualification will be given preference.

Send application to

Please send applications to Dr. Ali Sak, e-mail: ali.sak@uni-due.de. (cover letter, recent CV, names of reference with contact details).

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About Universitätsklinikum Essen

Das Universitätsklinikum Essen ist ein Zentrum der medizinischen Spitzenversorgung, das für die Gesundheitsversorgung der Menschen im Ruhrgebiet von grosser Bedeutung ist. Als Krankenhaus der Maximalversorgung verfügt es heute über rund 50 Kliniken und Institute mit einer Kapazität von 1.322 Betten und über 5500 Mitarbeitern. In den Forschungsschwerpunkten...

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