PhD Position (m/f)

PhD Position (m/f)

(parttime, 67%)

The Clinic of Medicine I of the University Hospital Heidelberg is looking for one PhD.

Head and PI: Prof. Dr. Peter Nawroth

Project Title: Mechanisms and function of methyglyoxal induced hormesis for the development of diabetic late complications

Application deadline: August 31st, 2018

Start of PhD project: October 01st, 2018

Source of funding: DFG CRC 1118 (funding until June 2022)

Project description:
Hormetic effects, meaning that low levels of a toxic substance can have positive effects on an organism, have been proven for a variety of substances, including radiation or reactive oxygen species (ROS). Lately, we were able to show that the reactive dicarbonyl methylglyoxal (MG), which is formed non-enzymatically during glycolysis, can also exert a hormetic response leading to increased resistance towards toxic levels of MG but also ROS. This increased resistance is achieved by up-regulation of detoxifying enzymes but also of the protein quality control system, including heatshock protein 70 (Hsp70). Pharmacological induction of Hsp70 in diabetic mice leads to reduction of hyposensitivity in case of diabetic neuropathy. Furthermore, we found that Hsp70 expression levels are reduced in patients with diabetic nephropathy. This project will aim to understand the function of Hsp70, as part of MG-hormesis, in handling of MG-modified proteins in vitro and in vivo in the context of diabetic nephropathy.

Methods that will be used:
  • Biochemical analysis of post-translational modifications associated with reactive metabolites
  • Chaperone biochemistry
  • Molecular biology
  • Genomics and proteomics
  • Fluorescence microscopy
  • (Immuno-)Histochemistry
  • Cell culture based methods
  • Mouse handling
Profile of candidate’s qualification:
We are looking for a highly motivated PhD student (m/f) with a keen interest in diabetes research and regenerative medicine, in an environment that truly thinks and works from bench to bedside. Previous experience in working with cell culture and molecular biology techniques would be an advantage. The candidate should be comfortable to work in a young team of international researchers with both medical and biochemical background. Due to the collaborative nature of the project, excellent communication skills and working efficiently both independently and as part of a team are required as well as a Master’s Degree in Life Sciences acceptable to HBIGS.

Contact & Application:
Please send your application only via the HBIGS Graduate School Application System (position Zemva_Nawroth0118); http://www.hbigs.uni-heidelberg.de/ .

Universitätsklinikum Heidelberg
Zentrum für Innere Medizin
Klinik für Endokrinologie, Stoffwechsel und Klinische Chemie
(Innere Medizin I)
Prof. Dr. Peter Nawroth 
Im Neuenheimer Feld 410
69120 Heidelberg



Wir stehen für Chancengleichheit. Schwerbehinderte werden bei gleicher Eignung vorrangig eingestellt. Das Universitätsklinikum strebt eine generelle Erhöhung des Frauenanteils in allen Bereichen und Positionen an, in denen Frauen unterrepräsentiert sind. Qualifizierte Frauen sind daher besonders aufgefordert, sich zu bewerben. Vollzeitstellen sind grundsätzlich teilbar, soweit dienstliche oder rechtliche Gründe nicht entgegenstehen.
Send application to
Please send your application only via the HBIGS Graduate School Application System (position Zemva_Nawroth0118); http://www.hbigs.uni-heidelberg.de/ .

Universitätsklinikum Heidelberg
Zentrum für Innere Medizin
Klinik für Endokrinologie, Stoffwechsel und Klinische Chemie (Innere Medizin I)
Prof. Dr. Peter Nawroth 
Im Neuenheimer Feld 410
69120 Heidelberg
While applying for the job please refer to jobvector

About Universitätsklinikum Heidelberg

Das Universitätsklinikum Heidelberg ist eines der bedeutendsten medizinischen Zentren in Deutschland und steht für die Entwicklung innovativer Diagnostik und Therapien sowie ihre rasche Umsetzung für den Patienten. Mit rund 10.000 Mitarbeiterinnen und Mitarbeitern in mehr als 50 klinischen Fachabteilungen mit ca. 1.900 Betten werden jährlich rund 66.000 Patienten voll- bzw. teilstationär und...

More about Universitätsklinikum Heidelberg

Get jobs on a daily basis for free

Keywords:
Filters:

*Your email address will not be shared with third parties. By submitting the form you agree to our Terms and Conditions and Privacy Policy.