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PhD position

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The Institute of Physiology I, University of Bonn Medical School, Germany invites candidates for a DFG-funded
 
PhD position (TV-L EG13, 65%)
 
The position starts as soon as possible and is funded for a period of 3 years.
 
The DFG-project entitled „Direct G protein modulation under physiological and pathophysiological conditions in the lung“ is part of the recently approved DFG-funded network FOR 2372 “G protein signaling cascades: With new molecular probes and modulators towards novel pharmacological concepts” and focuses on the therapeutic effects of a new pharmacological Gq protein inhibitor on vascular and airway function in the lung.
 
Our laboratory employs a wide array of experimental techniques including cell biology, molecular biology, protein biochemistry (cell culture work, lentiviral transduction, magnetic nanoparticles, qRT-PCR, Westen Blot analysis) and physiology (Ca2+ imaging, isometric force measurements, functional lung slices, pressure catheter measurements). Results are transferred to experimental mouse models of lung disease.

The ideal candidate will be a highly motivated graduate with an university degree in (Veterinary)medicine, Biology, Biomedicine, Biochemistry or a related subject. She/he has a strong interest in application-oriented basic research and is willing to work with mice. Experience with cell biology, physiology and/or animal experimentation techniques is desired. Good English skills are expected.
 
The Institute of Physiology I is located in the Life&Brain Center of the University of Bonn with state-of-the-art equipment. We provide excellent training and research infrastructure, supportive mentoring and a highly interactive and stimulating environment.
 
We offer salary according to the German salary scale TV-L E13, Jobticket and supplementary benefits in the public sector (pension plan according to VBL).
 
The University of Bonn is an equal opportunity employer.
Please submit your application (including CV, copies of your education certificates, a motivation letter, a brief summary of previous research experience, contact information of 2 referees) within the next 3 weeks via email in a single pdf file to:
 
Jun.-Prof. Dr. med. Daniela Wenzel
Institut für Physiologie I
Universitätsklinikum Bonn
e-mail: dwenzel@uni-bonn.de
 
or
 
Prof. Dr. med.(I) Bernd Fleischmann
Institut für Physiologie I
Universitätsklinikum Bonn
Tel.: 0228-6885-200
e-mail: dwenzel@uni-bonn.de
 
 
 
 
Literature:
 
Wenzel D, Knies R, Matthey M, Klein AM, Welschoff J, Stolle V, Sasse P, Roell W, Breuer J, Fleischmann BK. The b2-adrenoceptor antagonist ICI 118,551 decreases pulmonary vascular tone in mice via a Gi/o protein/nitric oxide-coupled pathway. Hypertension. 2009; 54:157-163.
 
Wenzel D, Matthey M, Bindila L, Lerner R, Lutz B, Zimmer A, Fleischmann BK.Endocannabinoid anandamide mediates hypoxic pulmonary vasoconstriction. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18710-5.
 
Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E. The experimental power of FR900359 to study Gq-regulated biological processes. Nat Commun. 2015 Dec 14;6:10156.
 
 

Contact detail


How to apply:
per email
Send application to
Jun.-Prof. Dr. med. Daniela Wenzel
Institut für Physiologie I
Universitätsklinikum Bonn
e-mail: dwenzel@uni-bonn.de
 
or
 
Prof. Dr. med.(I) Bernd Fleischmann
Institut für Physiologie I
Universitätsklinikum Bonn
Tel.: 0228-6885-200
e-mail: dwenzel@uni-bonn.de
 

Job profile


Working hours
Full-Time
Contract duration
Temporary
Type of job
PhD Project
Work experience
job experience is not required
Region
Germany (Nordrhein-Westfalen)
Working place
53127 Bonn
Area of expertise
Human medicine, Biology & Life Sciences, Pharmaceutics, Veterinary Medicine
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