PhD position: Patch Clamp of endo-lysosomal ion channels

More than 70 different ion channels and transporters are harbored in membranes of intracellular compartments such as endosomes and lysosomes. Malfunctioning of these channels has been implicated in human diseases such as lysosomal storage disorders, neurodegenerative and metabolic diseases, as well as in the progression of certain infectious diseases. As a consequence, these channels have engendered very high interest as future drug targets. Our group, is one of a few groups worldwide, which has established the manual patch clamp technique for endo-lysosomes.

We are currently looking for recent graduates (Pharmacy, Master of Science in biology, chemistry, pharmaceutical sciences or similar) who are interested in learning and applying this technique with a particular focus on the endolysosomal ion channels, i.e. TRPML cation channels (mucolipins) and two-pore channels (TPCs). We are looking for candidates with high intrinsic motivation and a drive for scientific innovation and discovery. The candidate would ideally have experience in molecular biological techniques and would have strong interest in patch-clamp electrophysiology. 

Selected recent publications:
1) Chao et al. PNAS 114: E8595–E8602, 2017 
2) Chen et al. Nat. Protoc. 12:1639-1658, 2017.
3) Butz et al. Nat. Protoc. 11:2470-2498, 2016.
 

Activities and responsibilities

The PhD student will work with cell culture and native cells and will mainly perform patch clamp as well as other molecular biological and biochemical techniques.

Qualification profile

Qualified and highly motivated candidates are invited to apply for this position. The candidate would ideally have  strong interest in patch-clamp electrophysiology.

Benefits

PhD in internationally recognized institute
Project supervision and support 
Publications in top journals 
local, national and international collaborations

Send application to

Medizinische Hochschule Hannover
Prof. Dr. Christian Wahl-Schott
Institut für Neurophysiologie, OE 4230
Carl-Neuberg-Straße 1
30625 Hannover
wahl-schott.christian@mh-hannover.de

While applying for the job please refer to jobvector and use the following reference number: endo-lysosomal patch clamp

About Medizinische Hochschule Hannover

Lehrstuhl Neurophysiologie von Herrn Prof. Dr. Christian Wahl-Schott  
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