PhD student in a project aiming to identify the mechanisms underlying the intestinal microbiota orchestrated induction, maintenance and breaking of tolerance to non-self-antigens (m/f/d) within the Collaborative Research Centre (CRC) 1371

The Technical University of Munich (TUM) is one of Europe’s top universities. It is committed to excellence in research and teaching, interdisciplinary education and the active promotion of promising young scientists.

CRC 1371 (Speaker Prof. Dr. Dirk Haller, Department of Nutrition and Immunology, TUM) focuses on the digestive tract and proposes an interdisciplinary approach to characterizing the functional relevance of microbiome signatures in the context of inflammation and cancer.

Activities and responsibilities

We offer exciting, interdisciplinary, experimental work on highly relevant issues in immunological and allergological research with the following main research areas:
  • Role of the intestinal microbiome for immunological tolerance to food
  • Importance of the intestinal microbiome for the disruption of tolerance and the development of allergy
The project, funded by the DFG through the SFB1371 "Functional Relevance of Microbiome Signatures in the Digestive Tract", investigates the importance of the intestinal microbiome for the development and maintenance of immunological tolerance to food and the extent to which the composition of the intestinal microbiome can promote the development of food allergies. Most of the models and methods have already been established: In vivo anaphylaxis models as well as systems for in vitro and ex vivo investigation of the interaction of mast cells, T-cells, dendritic cells and other immune cells. FACS, ELISA, real-time PCR and Western blot will be used for the analysis. In addition to the mouse model, we also have patient cohorts. These are, for example, patients with food allergies. Those will be compared to people who are tolerant to these foods. The analysis of the intestinal microbiome allows the comparison of immunological processes with the outcome `tolerance´ versus `allergy´ in the mouse model and also in humans.

Qualification profile

Candidates hold a Master degree (or equivalent) in Biology, Molecular Biology or Biochemistry They are open minded, active and have a good command of the English language (oral and written).

Application
Applicants are asked to send one pdf file to the contact person. The file includes
  • cover letter,
  • curriculum vitae,
  • copies of academic degrees and transcripts of records,
  • preferences of projects (optional),
  • contact information for at least one letter of recommendation,
  • list of publications with link for downloading (Do not include your publications in the pdf file).

Benefits

Within CRC 1371, the Integrated Research Training Group (IRTG) provides a qualification program for PhD students containing excellent multidisciplinary training with tailor-made subject-based and soft skills courses, annual retreats, summer school, and a supervision concept.

Salary and duration
Payment is according to the wage agreement of the civil service TV-L, 65% of E13 for PhD student positions for 4 years.

As an equal opportunity and affirmative action employer, TUM explicitly encourages applications from women as well as from all others who would bring additional diversity dimensions to the university’s research and teaching strategies. Preference will be given to disabled candidates with essentially the same qualifications.

Send application to

Univ.-Prof- Dr. med. Tilo Biedermann MD
Chairmann
Department of Dermatology and Allergology
Technical University of Munich
Biedersteiner Str. 29
80802 Munich
Tilo.biedermann@tum.de

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About Technical University of Munich

The CRC 1371 (Speaker Prof. Dr. Dirk Haller, Department of Nutrition and Immunology, Technical University of Munich) is a DFG-funded Collaborative Research Centre with its hub at the Technical University of Munich, TUM School of Life Sciences Weihenstephan, TUM School of Medicine and at the Klinikum rechts der Isar. The consortium further exists of strong partners at European Molecular Biology...

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